Henoch-Schonlein purpura (HSP) is a disease involving inflammation of small blood vessels. It most commonly occurs in children. The inflammation causes blood vessels in the skin, intestines, kidneys, and joints to start leaking.The main symptom is a rash with numerous small bruises, which have a raised appearance, over the legs or buttocks.
Henoch-Schonlein purpura is a small vessel vacuities in which complexes of immunoglobulin A (IgA) and complement component 3 (C3) are deposited on arterioles, capillaries, and venules. As with IgA nephropathy, serum levels of IgA are high in HSP and there are identical findings on renal biopsy. A diagnosis of Henoch-Schonlein purpura is fairly easy to make if the classic rash, joint pain and gastrointestinal symptoms are present. If some of these signs and symptoms are missing, the following tests have to be done lab testes , biopsies, and imaging tests.
Henoch-Schonlein purpura usually improves on its own within a month with no lasting ill effects. Bed rest, plenty of fluids and over-the-counter pain relievers may help. In Henoch-Schonlein purpura, some of the body's small blood vessels become inflamed, which can cause bleeding in the skin, joints, abdomen and kidneys.
Annual incidences of childhood cases of HSP in Scotland ranged from 20.3 to 26.7 per 100,000 of the child population over 1995-2007. Quarterly rates were highest in winter and lowest in summer. Monthly rates were highest in the months between December and March and consistently low in July and August.