Osteomalacia means "soft bones". Osteoid is the bone protein matrix, composed primarily of type 1 collagen. When there is insufficient mineral or osteoblast dysfunction, the osteoid does not mineralize properly, and it accumulates. The unmineralized osteoid has consistency similar to the tip of the nose, instead of the normal hard bone in the bridge of the nose.
This increase occurred mainly in women (64%) compared to men (19%) 13% of patients who have suffered a fracture die after 3 months and this figure rises to 38% after 24 months. Treatment can be as simple as vitamin D or as complex as parenteral nutrition. Orthopaedic surgery is frequently necessary. Patients with X-linked hypophosphatemic rickets usually are treated with a combination of calcitriol and phosphate supplements, and careful medical monitoring is needed.