Ameloblastoma is an odontogenic tumor arising from the epithelial rests of Malassez, occurring mostly in the mandible and the tumor arises from the epithelium that plays a role in the process of tooth development. A marked geographic variation is apparent in the relative incidences of various odontogenic tumors, particularly ameloblastoma. Ameloblastoma as, "Usually unicentric, non-functional, intermittent in growth, anatomically benign, and clinically persistent". In most cases, an ameloblastoma is usually asymptomatic, grows slowly, and can expand jaws. The case records and surgical biopsy reports of all diagnosed cases of ameloblastoma archived from January 2010 to December 2012 were retrieved from the Outpatient Department of Oral Medicine and Radiology, Vishnu Dental College, Bhimavaram, West
There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro.