Pathophysiology: Viral hemorrhagic fever (VHFs) is a general term to severe group of illness caused by RNA viruses from several viral families. It is a severe multisystem syndrome caused by infectious viruses which lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal (GI) bleeding.VHF is caused by viruses of four families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses.
Disease Statistics: Dengue fever is endemic in Singapore, where the risk is estimated to be between 1.6 and 6 per 10,000 transfusions.
Treatment: Patients usually receive supportive therapy but as such there are no other treatment or established cure for VHFs. Ribavirin, an anti-viral drug, have been effective in treating some individuals with Lassa fever or HFRS. Treatment with convalescent-phase plasma has been used with success in some patients with Argentine hemorrhagic fever.
Research: Major research is happening primarily in the Fatal dengue hemorrhagic fever. Some major research institute involved in the study are Department of Infectious Diseases, Tan Tock Seng Hospital and Department of Clinical Epidemiology, Tan Tock Seng Hospital in Singapore.