Coeliac disease appears to be multifactorial, both in that more than one genetic factor can cause the disease and in that more than one factor is necessary for the disease to manifest in a person. Almost all people (95%) with coeliac disease have either the variant HLA-DQ2 allele or (less commonly) the HLA-DQ8 allele. However, about 20–30% of people without coeliac disease have also inherited either of these alleles. This suggests additional factors are needed for coeliac disease to develop; that is, the predisposing HLA risk allele is necessary but not sufficient to develop coeliac disease. Furthermore, around 5% of those people who do develop coeliac disease do not have typical HLA-DQ2 or HLA-DQ8 alleles
In addition to digestive problems, other signs and symptoms of celiac disease include: Anemia, usually resulting from iron deficiency Loss of bone density (osteoporosis) or softening of bone (osteomalacia) Itchy, blistery skin rash (dermatitis herpetiformis) Damage to dental enamel Headaches and fatigue Nervous system injury, including numbness and tingling in the feet and hands, and possible problems with balance Joint pain Reduced functioning of the spleen (hyposplenism) Acid reflux and heartburn
1. Confirmed diagnosis. 2. Treatment begins. Treatment is a prescription - lifelong elimination of "gluten". You are going to be healthier. No surgery is required. No medication is required. The only known treatment for celiac disease to date is a gluten-free diet.
A prevalence of 9.1% (95% CI: 7.2-11.2) of CD in T1DM children was found. No significant difference in prevalence of CD was observed in different birth years, in contrast to the Swedish epidemic of CD. Sixty-two percent of children diagnosed with CD after T1DM onset had pathological levels of antibodies within the first 24 months. The presence or absence of gastrointestinal symptoms had no predictable value for biopsy-confirmed CD or not.