Common symptoms of HCL includes persistently feeling tired, weakness, weight loss for no reason, shortness of breath, excessive sweating (most often at night), swollen lymph nodes, frequent infections and fevers, small red spots on the skin. The main treatment for hairy cell leukemia is chemotherapy, purine analog drugs either cladribine (2-CdA) or pentostatin, monoclonal antibody rituximab, surgery or interferon alpha.
Aggressive surveillance and prevention efforts are generally warranted, although the lifetime odds of developing a second cancer after HCL diagnosis are still less than 50%. There is a decline in death rate during 2005-2010, for men and average of 3.2% and for women 3.1%. The corresponding figures for 2010-2015 were -0.8% and -0.2%, respectively.