Pathophysiology: Viral hemorrhagic fever (VHFs) is a general term to severe group of illness caused by RNA viruses from several viral families. It is a severe multisystem syndrome caused by infectious viruses which lead to a potentially lethal disease syndrome characterized by fever, malaise, vomiting, mucosal and gastrointestinal (GI) bleeding.VHF is caused by viruses of four families: arenaviruses, filoviruses, bunyaviruses, and flaviviruses.
Disease Statistics: In Sweden hemorrhagic fever with renal syndrome caused by hantavirus are mainly observed. Several studies on hemorrhagic fever with renal syndrome caused by Puumala virus are also been done.
Treatment: Patients usually receive supportive therapy but as such there are no other treatment or established cure for VHFs. Ribavirin, an anti-viral drug, have been effective in treating some individuals with Lassa fever or HFRS. Treatment with convalescent-phase plasma has been used with success in some patients with Argentine hemorrhagic fever.
Research: Major research institutes involved are department of clinical microbiology, Umea University and Swedish Institute for Infectious Disease Control, Solna, Sweden. Several grants are provided by grants from the County of Västerbotten, the County Councils of Northern Sweden, the Medical Faculty of Umeå University.