Pulmonary fibrosis is a condition that causes lung scarring and stiffness. It develops when the alveoli, tiny air sacs that transfer oxygen to the blood, become damaged and inflamed. Body tries to heal the damage with scars, but these scars collapse the alveoli and make the lungs less elastic. Changes in the lungs can also increase the blood pressure in the pulmonary artery. This condition, called pulmonary hypertension, makes the heart work harder and it may fail.
Statistical analysis of pulmonary fibrosis around the Switzerland has given the result as the FL BARD1 and BARD1β were upregulated in response to TGF-β in epithelial cells and fibroblasts in vitroand in vivo. Protein and mRNA expression studies showed very low expression in healthy lung tissues, but upregulated expression of full length (FL) BARD1 and BARD1β in fibrotic tissues. Many people diagnosed with pulmonary fibrosis are initially treated with a corticosteroid.