Ameloblastoma is an odontogenic tumor arising from the epithelial rests of Malassez, occurring mostly in the mandible and the tumor arises. The percentage of ameloblastoma occurrence among males and females has been reported with varied opinions in literature. Many studies have been published on the distribution of the ameloblastoma describing its demographic parameters, and there have been several case series on ameloblastomas from several countries, with geographical and/or racial variations.
Histopathology will show cells that have the tendency to move the nucleus away from the basement membrane. This process is referred to as "Reverse Polarization". While chemotherapy, radiation therapy, curettage and liquid nitrogen have been effective in some cases of ameloblastoma, surgical resection or enucleation remains the most definitive treatment for this condition.
There is evidence that suppression of matrix metalloproteinase-2 may inhibit the local invasiveness of ameloblastoma, however, this was only demonstrated in vitro. There is also some research suggesting that α5β1 integrin may participate in the local invasiveness of ameloblastomas.