Fibrous dysplasia is an uncommon bone disorder characterized by an abnormal bone growth where normal bone is replaced with fibrous bone tissue. This can cause deformation and fracture of the bones. It is non-neoplastic tumor-like congenital process.
Fibrous dysplasia is linked to a gene mutation that affects the cells that produce bone. The medullary cavity of bones is filled with fibrous tissue, causing the expansion of the areas of bone involved. The bony trabeculae are abnormally thin and irregular in shape. The cause of this may be linked to transcription factor C-fos. The activity of C-fos increases, leading to over expression of the gene, and hence tumor formation.
Usually, no treatment is required as the bone lesions usually do not progress beyond puberty. As for drugs, pain killer and supplements are given. In severe cases surgery is preferred.Fibrous Dysplasia Treatment. Surgery may be necessary for more problematic cases of fibrous dysplasia involving chronic pain, fractures, or deformity.
Fibrous dysplasia is a rare disease with estimated prevalence between 1/1,00,000 and 1/10,00,000. Gonadotrophin-independent precocious puberty is far more common in affected girls than in boys. Other manifestations of Fibrous dysplasia probably occur equally in both sexes. Sporadic and not associated with transmission from generation to generation.