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Heart Murmurs

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  • Heart murmurs

    Murmur is the sound of blood streaming. It might be going through a heart valve that has issues, for example or it might be that a condition is making your heart beat speedier, constraining your heart to handle more blood quicker than normal. Murmurs might likewise be the consequence of different issues, for example, narrowing or spilling of valves, or the vicinity of abnormal entries through which blood streams in or close to the heart. Such murmurs, known as pathologic murmurs, ought to be assessed by a specialist. Heart murmurs are most often ordered by timing, into systolic heart murmurs and diastolic heart murmurs, contrasting in the part of the heartbeat on which they can be listened. On the other hand, continuous murmurs can't be straightforwardly put into either class.

  • Heart murmurs

    Typical symptoms:

    In the event that you have a safe heart murmur, all the more generally known as an innocent heart murmur, you likely won't have some other signs or symptoms. An irregular heart murmur may bring about no undeniable different signs or symptoms, beside the uncommon sound your doctor hears when listening to your heart with a stethoscope. In any case, on the off chance that you have these signs or symptoms, they may demonstrate a heart issue.

  • Heart murmurs

    Meeting a medical practitioner:

    Most heart murmurs aren't serious, but if you think you or your child has a heart murmur, make an appointment to see your family doctor. Your doctor can tell you if your heart murmur is innocent and doesn't require any further treatment or if an underlying heart problem needs to be further examined.

  • Heart murmurs

    Therapeutic aspects:

    If treatment is necessary, it depends on what heart problem is causing the murmur and may include medications or surgery.

    Medications:

    •Anticoagulants

    •Beta blockers

    Diuretics

    •Statins

    •Angiotensin-converting enzyme (ACE) inhibitors

    Surgery:

    Numerous valve conditions can't be treated with solutions alone. Contingent upon your heart condition, your specialist may prescribe one of these choices to treat a harmed or leaky valve.

    Repair of valve:

    •Repair of structural support

    Annuloplasty

    •Valve leaflet repair

    •Balloon valvuloplasty

    Replacement of valve:

    •Open-heart surgery

    •Transcatheter aortic valve replacement (TAVR)

    Specialists used to prescribe that a great many people with irregular heart murmurs take antibiotics before going to the dentist or having surgery because of conceivable complexities from a bacterial contamination that influences the covering of your heart (infective endocarditis).

    Specialists no more prescribe antibiotics before methodology, aside from individuals at most elevated danger of complexities of infective endocarditis, for example, the individuals who have a simulated heart valve or individuals with certain intrinsic heart deformities.

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    Is correction of iron deficiency a new addition to the treatment of heart failure?
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  • Ahmed Zeidan
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  • Yosef Yarden
    Classically, the 3’untranslated region (3’UTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3’UTR alone, without all other elements in mRNA such as 5’UTR and coding region. The importance of independent 3’UTR RNA (referred as I3’UTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3’UTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3’UTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3’UTR were important for its tumor suppression activity. Then, the C/EBP 3’UTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3’UTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3’UTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990’s to 2000’s, world scientists found several 3’UTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3’UTR regions, although the existence of their transcribed products as independent 3’UTR RNAs is still to be confirmed. Our studies indicate that the independent 3’UTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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  • Ishfaq A Bukhari
    Protective Effect of Diltiazem and Fenofibrate Against Ischemia-reperfusion Induced Cardiac Arrhythmias in the Isolated Rat Heart.
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