Hookworms are parasites. This means they live off other living things. Hookworms affect your lungs and small intestine. Humans contract hookworms through roundworm eggs and larvae found in dirt contaminated by feces.
Symptoms include abdominal pain, colic (cramping and excessive crying in infants), intestinal cramps, nausea, fever, blood in your stool, appetite loss, itchy rash.
Most cases of classic hookworm disease can be managed on an outpatient basis with anthelmintic and iron therapy, complemented by appropriate diet. Patients with anemia and malnutrition may require both iron supplements and nutritional support (including folate supplementation). Some patients with severe anemia and congestive heart failure may require hospitalization.
In the developed world, declining prevalence of parasitic infections correlates with increased incidence of allergic and autoimmune disorders. Current treatments for these chronic inflammatory conditions have little to no effect on their prevalence and are referred to as “controllers” rather than cures. There has been limited success in therapeutically targeting allergic and autoimmune pathways, leaving an unmet need for development of effective anti-inflammatories.