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Sclerosing Mesenteritis

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  • Sclerosing mesenteritis

    Sclerosing mesenteritis occurs when the tissue mesentery that holds the small intestines in place becomes inflamed and forms scar tissue.Sclerosing mesenteritis can cause abdominal pain, bloating and diarrhea. In rare cases, scar tissue formed by sclerosing mesenteritis can block food from moving through your digestive tract. Surgery may be necessary in this situation.

  • Sclerosing mesenteritis

    sclerosing mesenteritis is asymptomatic, gastrointestinal symptoms such as abdominal pain, nausea/vomiting, bloating, loss of appetite, weight loss and diarrhea or constipation, Occasionally, intermittent partial bowel obstruction is encountered. Non-gastrointestinal symptoms include fatigue, weight loss, night sweats and fever.
    Pathophysiology:
    Includes abdominal surgery or trauma , autoimmunity , paraneoplastic syndrome, ischaemic injury and infection.small bowel mesentery is affected in most cases although the sigmoid mesocolon and omentum can also be occasionally be involved. The disease includes three stages.
    Stage-1: mesenteric lipodystrophy, degeneration of mesenteric fat.
    Stage-2: mesenteric panniculitis, inflammatory reaction.
    Stage-3: retractile mesenteritis / sclerosing mesenteritis, fibrosis, which may be associated with distortion or lymphatic obstruction.

  • Sclerosing mesenteritis

    Diagnosis:
    Tests and procedures used to diagnose sclerosing mesenteritis include.
    1. Physical exam: sclerosing mesenteritis often forms a mass in upper abdomen that can be felt during a physical exam.
    2. Imaging tests: Imaging tests of your abdomen may reveal sclerosing mesenteritis. Imaging tests may include computerized tomography or magnetic resonance imaging.
    3. Biopsy: Removing a sample of tissue for testing.
    Treatment:
    Glucocorticoid drugs such as prednisone, which relieve inflammation. They may be used in combination with azathioprine and colchicine.Hormonal therapy such as tamoxifen has also been shown to work. Sometimes hormonal therapy is used together with glucocorticoid drugs.Several other medications such as azathioprine, colchicine, Cyclophosphamide and thalidomide.

 

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