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conferenceseries
.com
Volume 7
Molecular Biology: Open Access
Molecular Biology Meet 2018
August 27-28, 2018
August 27-28, 2018 Dubai, UAE
Molecular Biology and Medicine
International Conference on
Life supporting molecular dynamics under extreme thermal environments
Ved Pal Singh
1
, Hari Ram
2
and Shikha Srivastava
2
1
Innovative College of Pharmacy, India
2
University of Delhi, India
I
n the era of global warming, there has been a tremendous concern over as to how life can support itself under extreme
temperature regimes. The most primitive bacteria could be used as an ideal model system to look into the molecular dynamics
for understanding the biochemical basis of thermophily. The signature molecule of prokaryotes happens to be the DNA which
can undergo dynamic change with change in the temperature conditions where bacteria could survive comfortably. The model
of nucleotide diversity in psychrophilic, mesophilic and thermophilic bacteria and established that transformation of DNA base
composition could enable these organisms to thrive best at their respective optimal growth temperatures, where the frequency of
GC base pairs increased with increase in growth temperature from psychrophilic to thermophilic and the frequency of AT base
pair decreased with decrease in growth temperature from thermophilic to psychrophilic and vice versa. The other macromolecular
attribute, that could support life at high temperature, pertains to rapid turnover of molecules including enzymatic proteins which
could serve as the basis for high temperature adaptation, in which macromolecular charged environment and ordered cellular
organization contributed significantly for sustainability of life under diverse extreme temperature conditions.
vpsingh_biology@rediffmail.comMol Biol 2018, Volume 7
DOI: 10.4172/2168-9547-C1-003
Notes: