translational-medicine-and-oncologists-meet-2016_posters

2 / 18

Volume 6, Issue 4(Suppl) Transl Med 2016
ISSN: 2161-1025, an open access journal
Page 62
Notes:
conferenceseries.com
Translation Medicine & World Oncologists 2016
November 28-30, 2016
Translational Medicine and Oncologists Meet
November 28-30, 2016 San Francisco, USA
14th Annual Conference on
Phospholipase Cγ1 links inflammation and tumorigenesis in colitis-associated cancer
Kwangil Park
Korea Institute of Oriental Medicine, Republic of Korea
C olorectal cancer is linked to inflammation and phospholipase C 1 (PLC γ1) is associated with tumorigenesis and the development
of colorectal cancer; however, evidence of mechanisms connecting them remains unclear. Here we found that PLC γ1 regulated
colitis and tumorigenesis in intestinal epithelial cells (IEC). In a colitis-associated cancer model, we showed that the deletion of
PLC γ1 in IEC decreased the incidence of tumors by enhancing apoptosis and inhibiting proliferation during tumor development.
Accordingly, the deletion of PLC γ1 in IEC reduced colitis-induced epithelial inflammation via inhibition of pro-inflammatory
cytokines and mediators. The PLC γ1 pathway in IEC accelerated colitis-induced epithelial damage via regulation of tight junction
(TJ) proteins. Our findings suggest that PLC γ1 is a critical regulator of colitis and colorectal cancer and could further help in the
development of therapy for colitis-associated cancer.
Biography
Kwangil Park has been conducted the “An effect of anti-inflammatory and anti-cancer by natural products”. He investigated the compounds and extract isolated from natural
products modulate on transcription and translation pathway, and using the mechanism underlying its action.
Kwang Il Park, Transl Med 2016, 6:4(Suppl)