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Volume 6, Issue 4(Suppl)

Transl Med 2016

ISSN: 2161-1025, an open access journal

Page 62

Notes:

conferenceseries

.com

Translation Medicine & World Oncologists 2016

November 28-30, 2016

Translational Medicine and Oncologists Meet

November 28-30, 2016 San Francisco, USA

14

th

Annual Conference on

Phospholipase C

γ

1 links inflammation and tumorigenesis in colitis-associated cancer

Kwangil Park

Korea Institute of Oriental Medicine, Republic of Korea

C

olorectal cancer is linked to inflammation and phospholipase C

1 (PLC γ1) is associated with tumorigenesis and the development

of colorectal cancer; however, evidence of mechanisms connecting them remains unclear. Here we found that PLC γ1 regulated

colitis and tumorigenesis in intestinal epithelial cells (IEC). In a colitis-associated cancer model, we showed that the deletion of

PLC γ1 in IEC decreased the incidence of tumors by enhancing apoptosis and inhibiting proliferation during tumor development.

Accordingly, the deletion of PLC γ1 in IEC reduced colitis-induced epithelial inflammation via inhibition of pro-inflammatory

cytokines and mediators. The PLC γ1 pathway in IEC accelerated colitis-induced epithelial damage via regulation of tight junction

(TJ) proteins. Our findings suggest that PLC γ1 is a critical regulator of colitis and colorectal cancer and could further help in the

development of therapy for colitis-associated cancer.

Biography

Kwangil Park has been conducted the “An effect of anti-inflammatory and anti-cancer by natural products”. He investigated the compounds and extract isolated from natural

products modulate on transcription and translation pathway, and using the mechanism underlying its action.

[email protected]

Kwang Il Park, Transl Med 2016, 6:4(Suppl)

http://dx.doi.org/10.4172/2161-1025.C1.020