Hirschsprung (HERSH-sproong) disease affects the large intestine (colon) of newborns, babies, and toddlers. The condition in which prevents bowel movements (stool) to pass through the intestines due to missing nerve cells in the lower part of the colon is caused by a birth defect. Most of the time, the problems with pooping start at birth, although in milder cases symptoms may appear months or years later. Hirschsprung disease can cause constipation, diarrhea and vomiting and sometimes lead to serious colon complications, like enterocolitis and toxic megacolon, which can be life-threatening. So, it's important that Hirschsprung disease be diagnosed and treated as early as possible.