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Parkinsonism

Parkinsonism complex of symptoms including resting tremor, bradykinesia/akinesia, rigidity, and postural instability that are due to striatal dopamine deficiency or reduced function; may be seen in a variety of neurodegenerative disorders including idiopathic Parkinson’s disease (PD) which is a long-term degenerative disorder of the central nervous system that mainly affects the motor system, Lewy body dementia, corticobasal degeneration, progressive supranuclear palsy, multisystems atrophy. Parkinson's disease can cause neuropsychiatric disturbances, which can range from mild to severe. This includes disorders of speech, cognition, mood, behaviour, and thought. Cognitive disturbances can occur in the early stages of the disease and sometimes prior to diagnosis, and increase in prevalence with duration of the disease.

Parkinsonism

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  • Micheal Ugrumov
    Neuroplasticity in the nigrostriatal system of MPTP-treated mice at presymptomatic and early symptomatic stages of Parkinsonism
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