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Multifunctional-auto processing rtx toxins are the unique family of secreted proteins toxins predominantly produced by the vibrio species. The best charac¬teristic of these toxins is produced by v. Cholerae. In the eukaryotic cell this toxin has three distinct biochemical activities resulting in autoprocessing, covalent crosslinking of actin and inactivation of rho-family gtpases, ultimately resulting in destruction of the actin cytoskeleton. Related toxins produced by v. Vulnificus and v. Anguillarum have some similar mechanisms of action. These toxins may assist the bacterium to evade host immune defences.
Related Journals: International Journal of Microbiology, International Journal of Scientific Research in Environmental Science and Toxicology, Journal of Natural Toxins, Archives of Environmental Contamination and Toxicology.