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conferenceseries
.com
Volume 8, Issue 5 (Suppl)
J Chromatogr Sep Tech, an open access journal
ISSN: 2157-7064
Chromatography 2017
August 07-09, 2017
August 07-09, 2017 | Rome, Italy
4
th
World Congress on
Chromatography
PATfixTM - At-line monitoring of impurities and critical quality attributes in biopharmaceutical up-
and downstream processes using HPLC fingerprinting
Aleš Štrancar
1
, Sebastijan Peljhan
1
, Tomas Kostelec
1
, Romina Žabar
1
, Blaž Goričar
1
, Vid Skvarča
1
, Vignesh Rajamanickam
2
, Valentin Steinwandter
3
and
Patrick Sagmeister
3
1
BIA Separations, Slovenia
2
Vienna University of Technology, Austria
3
Exputec GmbH, Austria
P
roduction of high value biological therapeutics usually involves complex manufacturing processes with high process
variability. Additionally, development of robust and reliable bioprocesses can be challenging. PAT aims to enhance
bioprocess understanding and implies a holistic approach to ensure that quality is built into products by design. Efficient PAT
therefore calls for fast and robust analytical techniques which enable to assess high quality information about critical quality
attributes and key performance indicators as parallel as possible to the manufacturing process. PATfix™ is unique HPLC system
for routine gradient separations that enables every analytical task. Equipped with bio-inert ceramic pump heads is deliberately
tailored to meet the demands of analytical applications covering wide range of biomolecules. Highly sensitive and fast multi-
wavelength detector enables to detect component peaks even in very fast gradients.
Biography
Aleš Štrancar is the CBDO of the BIA Separations and one of the main inventors of the CIM Convective Interaction Media®. He is author and co-author of more
than 60 scientific papers dealing with separation and purification technologies, a co-author of five granted USA patents and their foreign equivalents in the field of
biomolecule separations and purification and a co-author of several book chapters dealing with novel chromatography technologies for biomolecule separation. He
co-developed several industrial scale purification processes. He was the President of Technology Council of Ministry of Economy of the Republic of Slovenia and
Member of Science and Technology Council of the Republic of Slovenia.
ales.strancar@biaseparations.comAleš Štrancar et al., J Chromatogr Sep Tech 2017, 8:5(Suppl)
DOI: 10.4172/2157-7064-C1-032