genomics-integrative-biology-2018-posters

13 / 31

Page 97
Notes:
conferenceseries.com
Volume 12 Journal of Molecular and Genetic Medicine
ISSN: 1747-0862
May 21-23, 2018 Barcelona, Spain
&
Integrative Biology
6th International Conference on
Genomics and Molecular Biology
10th International Conference on
Genomics 2018 and Integrative Biology 2018
May 21-23, 2018
JOINT EVENT
SEQprocess: A pipeline tool for processing of next generation sequencing data with modularized
customization
Taewoon Joo1, Ji Hye Choi1, Ji Hye Lee1, So Eun Park1, Youngsic Jeon2, Sae Hoon Jung1 and Hyun Goo Woo1
1Ajou University School of Medicine, South Korea
2Yonsei University College of Medicine, South Korea
Next-Generation Sequencing (NGS) technology is now widely used in biomedical research field. The application of NGS
technologies includes the identification sequence variants of DNA or RNA and the quantitation of RNA abundances
or DNA copy numbers. Previously several softwares for NGS data processing pipelines have been released. However, the
softwares do not cover the recently updated GDC pipelines which is a standardized pipeline used in the processing of the
TCGA data. Moreover, there is no comprehensive tools that handle the recent clinical applications of NGS technology such
as cell-free DNA, small RNA, and exosomal RNA sequencing data. Here, we developed a SEQprocess that can provide NGS
processing pipelines covering the GDC pipeline as well as the new data for clinical applications. SEQprocess is implemented
in an R program to provide an automated and user friendly interfaces. SEQprocess also provide a flexible customization
framework by modularizing the multiple NGS processing steps that can be easily included or excluded in the process. In
addition, SEQprocess automatically generate a report that summarize the processing steps, which will ensure reproducibility
of the NGS data analysis.
Biography
Ji Hye Choi has completed her Doctor of Science Degree majoring in Biomedical Informatics and Convergence Medicine from Ajou University of Medicine, Suwon,
Republic of South Korea in August 2017 and currently is a Research Fellow at the same university. Her research interests are Genomics, Bioinformatics and System
Biology. She has authored more than five papers in reputed journals including Cancer Research, Nature communication, Experimental & Molecular Medicine,
Oncotarget and BMC Bioinformatics.
Taewoon Joo et al., J Mol Genet Med 2018, Volume 12
DOI: 10.4172/1747-0862-C2-028