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Volume 12
Journal of Molecular and Genetic Medicine
ISSN: 1747-0862
May 21-23, 2018 Barcelona, Spain
&
Integrative Biology
6
th
International Conference on
Genomics and Molecular Biology
10
th
International Conference on
Genomics 2018 and Integrative Biology 2018
May 21-23, 2018
JOINT EVENT
The protective effect of simvastatin against UVB-induced corneal endothelial cell death
Yi Ru Ho
1
and
Chan Yen Kuo
2, 3
1
Chan Bing Show Chwan Memorial Hospital, Taiwan
2
Hsin Sheng Junior College of Medical Care and Management, Taiwan
3
National Central University, Chungli, Taiwan
U
ltraviolet B (UVB) radiation is a risk factor for uveitis, and excessive UVB exposure causing corneal endothelium injury,
including apoptosis, is a serious condition. Therefore, drugs that can inhibit apoptosis in corneal endothelial cells represent
an effective strategy for treating uveitis. Simvastatin is widely used as a specific inhibitor of 3-hydroxy-3-methyl-glutaryl-CoA
reductase, can reduce levels of low density lipoprotein (LDL) cholesterol, and exerts anti-inflammatory effects. However, the
effect of simvastatin on uveitis remains unclear. Therefore, the aim of this study was to elucidate whether UVB promotes the
initiation of apoptosis in corneal endothelial cells and subsequently contributes to uveitic injury reversible by simvastatin
treatment. Our findings indicated that simvastatin alleviated UVB-induced corneal endothelial cell apoptosis via caspase-3
activity.
Biography
Yi-Ru Ho completed her Graduation from Department of Molecular Biology and Human Genetics, Tzu Chi Universit. Currently, she is a Research Assistant in
Department of Medical Research Chang Bing Show Chwan Memorial Hospital. She is interested in “Primary cell culture of ADMSC, cell culture of neuron cell, MTT
assay, DNA extraction, qPCR, Western blot, flow cytometry of cell cycle and cell marker, Luciferase assay, siRNA transfection, Enzyme-linked immunosorbent
assay, intraperitoneal injection of mice”.
ruki41004@gmail.comYi Ru Ho et al., J Mol Genet Med 2018, Volume 12
DOI: 10.4172/1747-0862-C2-028