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conferenceseries
.com
Volume 5, Issue 5 (Suppl)
Nat Prod Chem Res
ISSN: 2329-6836 NPCR, an open access journal
Pharmacognosy 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
5
th
International Conference and Exhibition on
Pharmacognosy, Phytochemistry
& Natural Products
Macrophage mediated host defense against Salmonella typhimurium by morus alba L
Sung Yeon Kim¹, BoYoon Chang¹, DaEun Kim¹, JiHye Park¹, BongSung Koo², Hyuncheul Lee²
1
Wonkwang University, Republic of Korea
2
ForBioKorea Co. Ltd., Republic of Korea
C
limatic effects are predicted to include crowding, famine, water contamination, human migration, and alterations in vector
ecology, all of which increase infectious diseases. The innate immune system, play a crucial part in the initiation and subsequent
direction of adaptive immune responses, as well as participating in the removal of pathogens that have been targeted by an adaptive
immune response. Moreover, because there is a delay of 4–7 days before the initial adaptive immune response takes effect, the innate
immune response has a critical role in controlling infections during this period. We evaluated that Morus alba extract enhance
immunostimulating activity and defense effects of Morus alba extract and pomace on bacteria infection mice model. The present
study was carried out to investigate the immunomodulating activity of Morus alba L. on the expression of Nitric Oxide (NO),
tumor necrosis factor alpha (TNF-α) and phagocytic uptake in macrophages. Multiple signaling molecules of the TLR4 signaling
pathway were also detected. We have chosen experimental bacterial infection with S. Typhimurium. Morus alba extract stimulated
the production of NO and TNF-α and phagocytic activity in RAW 264.7. Morus alba activated macrophages through the mitogen-
activated protein kinase and nuclear factor-κB signaling pathways downstream from TLR4. Morus alba extract and pomace enhances
the survival rate of salmonella infected mice by augmenting the phagocytosis activity of macrophages. The observed activation of
macrophage and induction of cytokines results on fruit of Morus alba L. treatment are the most probable reasons for the reduced
mortality of bacteria. The reported data clearly support the hypothesis that Morus alba L. acts as an immunomodulator. "This work
was supported by the Industrial Core Technology Development Program (10067293, Development of immunostimulatory feed
additive and vaccine adjuvants for animal from mulberry) funded by the Ministry of Trade, Industry and Energy (MOTIE, Korea)"
Biography
Sung Yeon Kim has completed PhD from Seoul University of Pharmacy. She is active in research activities in the field of medicinal plants. Several studies have
been published in various journals and presented various research papers by oral / poster at the national and international seminars
oama611@nate.comSung Yeon Kim et al., Nat Prod Chem Res 2017, 5:5 (Suppl)
DOI: 10.4172/2329-6836-C1-017