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conferenceseries
.com
Volume 5, Issue 5 (Suppl)
Nat Prod Chem Res
ISSN: 2329-6836 NPCR, an open access journal
Pharmacognosy 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
5
th
International Conference and Exhibition on
Pharmacognosy, Phytochemistry
& Natural Products
Novel protective effects of baicalin on high-glucose induced chick embryo malformation and its molecular
mechanisms
Jian-Xin Liang
1,2
, Lin-Rui Gao
2,3
, Li-Guo Chen
2
, Guang Wang
1,2,3
and Xue-Song Yang
1,3
1
Key Laboratory for Regenerative Medicine, China
2
Institute of Integrated Traditional Chinese and Western, China
3
Jinan University, China
B
aicalin, which is a traditional Chinese monomer isolated from a traditional Chinese tocolytic medicine; Baical skullcap root,
has shown the ability of anti-oxygenation. Here, we investigated for the first time whether baicalin treatment could improve the
high-glucose induced chick embryo malformation and uncovered its underlying mechanisms. In our study, we have found certain
concentration of baicalin did not affect the development of early chick embryo. The number of high-glucose induced heart tube
and blood island malformation in chick embryos were decreased in baicalin treating. Western blot analysis of the experimental
chick embryos revealed that GATA-4 was inhibited, while LC3-II and C-caspase-3 were increased following high glucose treatment.
However, baicalin treatment could improve the expression of these genes. In addition, we confirmed that the baicalin could improve
the cell survival through both anti-oxygenation and regulating autophagy
in vitro
. Therefore, our data indicated that baicalin could
be a potential candidate for gestational diabetes induced malformation.
545054487@qq.comNat Prod Chem Res 2017, 5:5 (Suppl)
DOI: 10.4172/2329-6836-C1-017