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conferenceseries
.com
Volume 5, Issue 5 (Suppl)
Nat Prod Chem Res
ISSN: 2329-6836 NPCR, an open access journal
Pharmacognosy 2017
July 24-25, 2017
July 24-25, 2017 Melbourne, Australia
5
th
International Conference and Exhibition on
Pharmacognosy, Phytochemistry
& Natural Products
A Sino-African pharmacokinetic comparison of berberine: The contribution of the intestinal microbiota
Raphael N Alolga
China Pharmaceutical University, China
B
erberine is one of the world’s most widely used natural products. It has gained recognition as a drug in many Asian and African
countries and also as a dietary supplement in many other countries. However, pharmacokinetic (PK) comparisons of berberine
in different racial/ethnic groups are lacking. Our study compared the PK differences of berberine in 20 healthy male Africans and
Chinese and investigated the possible underlying mechanisms for the racial differences. The plasma levels of berberine after oral
administration were monitored for 12 hours by liquid chromatography with mass spectrometry. The Cmax and AUC in the Africans
were 2.67-fold and 2.0-fold higher than the Chinese, respectively. Microbial compositions by 16S rRNA pyro sequencing showed
higher abundance of the genera
Prevotella, Bacteroides
and
Megamonas
(34.22, 13.88 and 10.68%, respectively) in the Chinese than
the Africans (30.08, 9.43 and 0.48%, respectively). Scatter plot showed a strong negative correlation between the microbial abundance
and the berberine AUC, especially for the genus
Prevotella
(
r
=-0.813) and its species. To confirm the effects of micro biota on the PK
of berberine, we compared the metabolic capacities of microbiota between the two races. A more extensive metabolism was observed
in Chinese with 1.83-fold higher metabolites, possibly contributing to the lower AUC than the Africans. In conclusion, significant
PK differences were observed between Africans and Chinese, which is partly attributable to variations in gut micro biota and its
corresponding metabolic capacity. Our findings are of clinical significance in the design of individualized dosage regimen based on
differential microbial compositions.
anammahime@gmail.comNat Prod Chem Res 2017, 5:5 (Suppl)
DOI: 10.4172/2329-6836-C1-017