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Volume 5, Issue 5 (Suppl)

Nat Prod Chem Res

ISSN: 2329-6836 NPCR, an open access journal

Pharmacognosy 2017

July 24-25, 2017

July 24-25, 2017 Melbourne, Australia

5

th

International Conference and Exhibition on

Pharmacognosy, Phytochemistry

& Natural Products

Evidence based validation of

Dendrobium fimbriatum

as a hepatoprotectant: An orchid from Northeast

India

Sunita Shailajan, Suhas Pednekar, Sasikumar Menon and Deepti Gurjar

Ramnarain Ruia College, India

D

endrobium fimbriatum

Hooker., is an important orchid found in Northeast India. It is used by the locals as traditional medicine

in resetting of fractured bones and possesses antioxidant activity. It has been reported to possess constituents like rhein,

fimbriatone, etc. However, there is a dearth of scientific data on its phytochemical and pharmacological evaluation. Thus, on the basis

of published reports, the present study was aimed to evaluate the hepatoprotective activity of hydroalcoholic extract of

Dendrobium

fimbriatum

stem in CCl4 intoxicated albino Wistar rats. The quality of the plant material was assessed and individual plant parts

were evaluated for the presence of active markers; ursolic acid, β-sitosterol and lupeol using a validated HPTLC and HPLC method.

Safety of the plant extract was established in albino Swiss mice following the OECD guidelines no. 420 and it was found to be safe up

to an oral dose of 2000 mg/kg body weight. Hepatoprotective activity of the extract of

Dendrobium fimbriatum

stem was studied at

three doses in terms of various biochemical parameters and histopathology. The results were compared with a known herbal drug,

Silymarin. Oral administration of the extract of

Dendrobium fimbriatum

stem showed hepatoprotective activity in a dose-dependent

manner and the results were at par with the positive control Silymarin. The results of histopathological observation were also found

to be in compliance with the findings of biochemical parameters analysis suggesting the possible use of

Dendrobium fimbriatum

as

hepatoprotective agent and forms baseline for future pharmacological investigations.

sunitashailajan@gmail.com

Nat Prod Chem Res 2017, 5:5 (Suppl)

DOI: 10.4172/2329-6836-C1-017