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Volume 5, Issue 5 (Suppl)

Nat Prod Chem Res

ISSN: 2329-6836 NPCR, an open access journal

Pharmacognosy 2017

July 24-25, 2017

July 24-25, 2017 Melbourne, Australia

5

th

International Conference and Exhibition on

Pharmacognosy, Phytochemistry

& Natural Products

Synthesis and

in vitro

antiplasmodial,

in vitro

antimycobacterial and

in vitro

cytotoxicity studies of oleanolic

acid and its ester

Victor O Fadipe

1

, Abayomi Oguntunde

1

, Hussaini Doko Ibrahim

2

and Andrew R Opoku

3

1

Federal Ministry of Science and Technology, Nigeria

2

Raw Materials Research and Development Council, Nigeria

3

University of Zululand, South Africa

T

uberculosis (TB) and malaria are chronic fatal diseases and attained a dangerous status worldwide. New drugs are therefore

needed to halt the mortality rate. Pentacyclic triterpenes, a group of naturally occurring compound have been reported to have

broad spectrum of biological activities that could be harnessed for development of new drugs for TB and malaria. In a quest to find

new antimalarial and anti-mycobacterial drugs, oleanolic acid (OA) was isolated from the flower buds of

Syzygium aromaticum

.

The derivative, 3-O-Acetyl-Oleanolic acid (OAA), was synthesized from the isolated product and their biological activities were

carried out and compared. The antiplasmodial and antimycobacterial activity of oleanolic acid and its derivative were subsequently

investigated against

Plasmodium falciparum

(Chloroquine Sensitive Strain) NF54 and

Mycobacterium tuberculosis

H

37

RV, respectively.

The compounds were evaluated for cytotoxicity activity using MTT (human embryonic kidney (HEK293) and human liver model

(HepG2)). OAA exhibited IC

50

of 4.3 µg/ml against

P. falciparum

while OA exhibited IC

50

of 27.4 µg/ml. OAA exhibited MIC

99

of

79.8 µg/ml against

M. tuberculosis

while OA exhibited MIC

99

of 73.1 µg/ml. The MTT test (HEK293 and HepG2) were in the range of

IC

50

≥300 μg/ml, indicating low toxicity level. The data obtained above, indicate that both compounds can serves as template for the

synthesis of potent anti-TB and anti-malaria drugs.

vobfadipe@yahoo.com

Nat Prod Chem Res 2017, 5:5 (Suppl)

DOI: 10.4172/2329-6836-C1-017