Encephalopathy is a general term describing a disease that affects the function or structure of your brain. There are many types of encephalopathy and brain disease. Some are permanent and some are temporary. Some are present from birth and never change, while others are acquired after birth and may get progressively worse. Symptoms include: Mental changes, Neurological symptoms like muscle weakness in one area, poor decision-making or concentration, involuntary twitching, trembling, difficulty speaking or swallowing and seizures. Diagnosed by blood tests, CT or MRI scan, EEG. Treatment may include medications or surgery to treat your symptoms or underlying cause.