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Lymphadenitis is the medical term for enlargement in one or more lymph nodes, usually due to infection. Lymph nodes are filled with white blood cells that help your body fight infections; a normal lymph node is small and firm. When lymph nodes become infected, they usually increase in size, become tender, and may be felt in other areas of your body during a physical exam, Infections that spread to lymph nodes are usually caused by bacteria, a virus, or a fungus.