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Journal of Tuberculosis and Therapeutics
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Submit manuscript at https://www.editorialmanager.com/biomedicaljournals/ or send as an e-mail attachment to the Editorial Office at tuberculosis@scholarlyjournals.org

About the Journal

Tuberculosis is an bacterial infection that can spread easily to any  organ through blood stream and lymph nodes. It can affect many parts of the body, but most often affects lungs.

Journal of Tuberculosis and Therapeutics is a peer reviewed journal focuses on the publication of basic experimental research on tuberculosis, pathological aspects of the disease and therapy involved during in treatment. Journal mainly focus on clinical research and epidemiological studies on tuberculosis, drug resistance during therapy.

Journal of Tuberculosis and Therapeutics accepts manuscripts in the form of original research articles, review articles, case reports, short communications, letters to editor and editorials for publication in an open access platform. The journal uses editorial managerial system for maintaining quality of the whole process of manuscript submission, peer review and tracking.

The journal is using Editorial Manager for quality peer-review process. Editorial Manager is an online manuscript submission, review and tracking systems. Review processing is performed by the editorial board members of Journal of Tuberculosis and Therapeutics or outside experts; at least two independent reviewers approval followed by editor approval is required for acceptance of any manuscript. Authors may submit manuscripts and track their progress through the system. Reviewers can download manuscripts and submit their opinions to the editor. Editors can manage the whole submission/review/revise/publish process.

Tuberculosis

It is an airborne Infectious disease caused by the bacterium Mycobacterium tuberculosis. It effects respiratory system and infects lungs in mammalian system. Tuberculosis can easily spread through air when TB active person cough, spit or sneeze. Active infection occurs more in people effected with HIV or who smoke. Symptoms of tuberculosis are cough with blood sputum, weight loss, fever.

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Mycobacterium tuberculosis

It is an obligate, pathogenic species which belongs to the family Mycobacteriaceae and the causative agent of tuberculosis. It was first discovered by Robert Koch in the year 1882. Mycobacterium is covered by a waxy layer on its surface due to the presence of mycolic acid. The cells are impervious to Gram’s staining (Gram negative staining) in clinical lab. Mycobacterium tuberculosis can appear red in colour on Acid fast staining.

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Mantoux test

Tuberculosis is identified in the laboratory by using one of the test called Mantoux test. It is more reliable and helps in the identification of TB Active persons. This test includes the procedure by injecting a small amount of PPD (Purified Protein Derivative) tuberculin intracutaneously. A small bubble is formed at the place where the tuberculin is injected. After 48-72 hours the test site will be examined. People who are exposed to tuberculosis will have a swelling at the place of injection, whereas TB negative person lacks the swelling.

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Tuberculin

Tuberculin is a mixture of antigens which are obtained from Mycobacterium tuberculosis. Antigens are the foreign particles which form a complex with antibodies. Two types of tuberculin are used: Old Tuberculin (OT) and Purified Protein Derivative (PPD).

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Multiple-drug therapy

Taking several antibiotics at a time is called as multiple drug therapy. Most of the medicines are given as pills. Antibiotics such as rifampin, ethambutol, isoniazid are used initially. Special treatment is provided to the people effected by HIV and TB, drug resistant TB, pregnant women with TB.

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Mycobacterial Journals, Tuberculosis Journals, American Journal of Tuberculosis

Antituberculous drugs

Mycobacterial cell wall is composed of mycolic acids. This layer provides resistance against several antibiotics. Mycobacteria produces beta lactamase enzyme, which can be resisted to beta lactam antibiotics, such as Penicillin and cephalosporin. Macrolides, Rifampicin, Aminoglycosides are effective against Mycobacterium.

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Pulmonary Tuberculosis

It occurs to the upper lobe of the right lung. Mycobacterium grow at high levels of oxygen and blood thus it effects lungs, and later on passes to other part of the body called as extrapulmonary tuberculosis. It is potentially deadly disease but it can be cured by medical help. Most of the people recover with primary TB. The infection may stay inactive for years, and it may become active again.

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Non-Pulmonary Tuberculosis

It is a serious disease of global importance. Non-Pulmonary TB is mostly common in females. Non-Pulmonary TB disease (meningitis, miliary, pericardial) it is suggested that empiric treatment be commenced while appropriate diagnostic samples are being obtained.

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Meningeal Tuberculosis

TB meningitis is caused by the bacterium Mycobacterium tuberculosis. TB meningitis is a life-threatening infectious disease that causes inflammation of the membranes that surround the brain and the spinal cord. These membranes are called the meninges – they help to protect the brain from injury and infection. The bacteria spread to the brain and spine from another place in the body.

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Tuberculous Pericarditis

Pericarditis caused by tuberculosis and it is difficult to diagnose, because diagnosis requires culturing Mycobacterium tuberculosis from aspirated pericardial fluid or pericardial biopsy. The Tygerberg scoring system helps the clinician to decide whether pericarditis is due to tuberculosis or whether it is due to another cause: night sweats, weight loss, fever, serum globulin > 40g/l, blood total leucocyte count <10 x 109/l; Pericardial fluid with an interferon-γ level greater than 50pg/ml is highly specific for tuberculous pericarditis.

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