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Metabolic flexibility is the capacity for the organism to adapt fuel oxidation to fuel availability. One of the major ways the body achieves this flexibility is through insulin. Insulin has powerful effects on the use of fuels. Namely, high insulin means carbs will be the preferred source of fuel, and low insulin means fat will be preferred. The inability to modify fuel oxidation in response to changes in nutrient availability has been implicated in the accumulation of intramyocellular lipid and insulin resistance The metabolic flexibility assessed by the ability to switch from fat to carbohydrate oxidation is usually impaired during a hyperinsulinemic clamp in insulin-resistant subjects; however, this “metabolic inflexibility” is mostly the consequence of impaired cellular glucose uptake.
Related Journals of Metabolic Flexibility
Journal of Diabetes & Metabolism, Journal of Metabolic Syndrome, Metabolic flexibility and insulin resistance, Metabolic Flexibility in Response to Glucose Is Not Impaired in People With Type 2 Diabetes After Controlling for Glucose Disposal Rate.