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Neonatal encephalopathy is a clinically defined syndrome of disturbed neurologic function in the earliest days of life in an infant born at or beyond 35 weeks of gestation, manifested by a subnormal level of consciousness or seizures, and often accompanied by difficulty with initiating and maintaining respiration and depression of tone and reflexes. This expanded clinical definition must be put into use based on measures that can be reliably and accurately implemented by trained staff. The first mandatory step in an assessment of neonatal encephalopathy is to confirm whether a specific infant meets the case definition.
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