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Pasteurella multocida toxin (PMT) is the major pathogenic determinant of pasteurella multorida. The species p. Mukorida causes various diseases of animals and human, the toxin is the causative agent of the economically important atrophic rhinitis in swine. Stimulation of several signalling pathways is induced by PMT. Most remarkable is a potent mitogenic effect. Phospholipase C and the small GTPase rho are activated due to stimu¬lation of heterotrimeric g proteins of the Gαq and Gα12/13 family.
Related Journals: Journal of Toxins, Journal of Pathogens, Journal of General Microbiology, Journal of Immunology.