Proinflammatory cytokines causes systemic inflammation. Due to their pro-inflammatory action they make the disease worse by producing fever, inflammation and tissue destruction. The net effect of an inflammatory response is determined by the balance between pro-inflammatory and anti-inflammatory cytokines.
Interleukin and tumor necrosis factor are proinflammatory cytokines, and when they are administered to humans, they produce fever, inflammation, tissue destruction, and in some cases, shock and death.
Related Journals of Proinflammatory cytokines
Journal of Cytokine biology, Journal of immunobiology, Journal of Clinical & Cellular Immunology, Immunome Research, Journal of Immunooncology, Journal of Molecular Immunology, Inflammatory Bowel Diseases, Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, Current Opinion in Anti-inflammatory and Immunomodulatory Investigational Drugs, Inflammatory Bowel Disease Monitor.