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Skin allergies can be caused by many things that includes immune system disorder, medications and infections. When you get a skin rash after contact with an allergy-causing substance doctors call it allergic contact dermatitis. It can be a devastating condition, "Patients with contact dermatitis can get a very itchy rash from head to toe, or in a confined area. Allergy is the response of the body's immune system to normally harmless substances, such as pollens, foods, and house dust mite.