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Advancing Skin Cancer Prevention: Nicotinamide and DNA Repair Enzymes
Historically, the public has looked to sunscreen as the primary method for prevention of skin cancer. However, fortunately there have been advancements in chemopreventative care for both precancerous lesion progression of Actinic Keratoses (AKs) and Non-Melanoma Skin Cancers (NMSCs) that have potential to be more patient-friendl.. Read More
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Predicting the Prognosis and Survival in Early-Stage Lung Cancer after Curative Surgery
Lung cancer remains one of the most important cancer-related mortality. More early-stage lung cancer is expected to be diagnosed, due to the use of low-dose computed tomography in lung cancer screening. Among all cell type, adenocarcinoma was the commonest among Asian population, with EGFR mutation being the commonest driver mut.. Read More
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The Implications of SFRP2 Gene Hypermethylation in Colorectal Cancer
Background: The Wnt pathway is stimulated by the DNA hypermethylation of SFRP2, which inhibits gene activity, downregulates the gene expression and promotes CRC. Objectives: This study aims to assess the prognostic impact of hypermethylation of SFRP2 in colorectal cancer. Methodology: The research used twenty (20) blood sample.. Read More
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MiR-124 could Inhibit CD151 Overexpression Associated with Non-Small Cell Lung Carcinoma Progression
Background: CD151 is a member of the transmembrane 4 super families and has been reported to be involved in cell adherence and migration. It has been reported that the overexpression of CD151 and the down regulation of miR-124 are all related to the progression of Non-Small Cell Lung Cancer (NSCLC). However, whether there is a r.. Read More
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Purpose: Glioblastoma is the most malignant primary adult brain tumor with a poor prognosis; therefore, novel therapies are needed. Natural Killer (NK) cells are promising candidates for immunotherapy because of their ability to eliminate tumor cells without prior sensitization. An inadequate number of NK cells remain a major ob.. Read More
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Background: Laboratory testing is a fundamental diagnostic and prognostic tool to ensure the quality of healthcare, treatment and responses. Our study initial goal was to evaluate the cost of the currently performed laboratory tests for patients who are undergoing chemotherapy treatments in our organization's Oncology Treatment .. Read More
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Improving Precision in Prognostication for the Elderly Population with Follicular Lymphoma
Follicular Lymphoma (FL) remains a highly heterogeneous entity with various outcomes. In some patients, the disease exhibits aggressive and chemotherapy-resistant behavior. On the other hand, the disease remains indolent with durable remissions after initial treatment. Such complexity in risk-stratifying patients is more so imp.. Read More
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Here, we report an exceedingly rare case of pulmonary cancer, composed of more than 70% Signet Ring Cells (SRC) in a Japanese male in his early 70s. Computed tomography detected the tumor shadow in the right lower lobe of the lung revealing a size of 1.1 cm × 0.7 cm × 0.7 cm. The SRCs were positive for Cytokeratin 7 (C.. Read More
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Objective: Cervical small cell carcinoma is a rare disease, with a high degree of malignancy and a poor prognosis. Para-aortic lymph nodes are common recurrence sites after pelvic chemoradiotherapy. Case report: A 26-year-old female patient with cervical small cell carcinoma who underwent two times of para aortic lymph node rel.. Read More
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Novel RNA Polymerase I Inhibitor CX-5461 Exhibits Antitumor Activity in Multiple Myeloma
rDNA transcription is steadily dysregulated in multiple myeloma, through oncogenes and anti-tumor routes, and particularly by c-Myc. The main downstream goals of c-Myc involve ribosomal biogenesis to enhance the protein translation capacity necessary to support the growth and self-renewal programs of malignancy cells. In the res.. Read More
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Immunotherapy in Advanced Solid Tumour
With the evolving understanding of the interaction between tumor and the immune system, novel therapies with sophisticated mechanisms of action are establishing themselves as the standards of care. In human cancer, the immune system plays a double edged sword with both protecting against tumor development as well as promoting tu.. Read More
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Correlation Morphometric Feature Analysis in Radiation Oncology
The information related to the shape and size of a tumour can be exploited from the morphometric feature analysis of medical images. The ability of extracting such features from a wide range of imaging modalities enables various clinical applications in radiation oncology. The morphometric features such as volume, surface area, .. Read More
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Background: Colorectal surgery is reported to have significant effects on patients, both physically and psychologically. On other hand, infections are found to be a major risk factor in Sudan and Sub-Saharan Africa such as intestinal Schist soma colitis, especially those presenting with sigmoid colonic adenocarcinoma. Aim of th.. Read More
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Small Cell Lung Cancer is Being Unveiled: Recent Advances are changing the Clinical Practices
SCLC remains one of the most lethal lung cancers with limited therapeutic options. In recent years, we have made many advances on pathogenesis, heterogeneity and mechanism of resistance in SCLC. Increasing studies demonstrate that SCLC is a highly heterogeneous tumor. According to differentially expressed Neuroendocrine (NE) neu.. Read More
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Enhancement of Cisplatin-Induced Apoptosis of Human Oral Squamous Cell Carcinoma by FBXW7
Background: About one-third of Oral Squamous Cell Carcinoma (OSCC) patients have a risk of occurrence and chemo resistance, making the survival abysmal. We aim to evaluate the role of F-Box/WD repeat-containing protein 7 (FBXW7) to further develop efficient treatment of chemo resistant OSCC. Methods: FBXW7 overexpression was in.. Read More
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Clinical Prevalence of Chemotherapy-Induced Peripheral Neuropathy in Onco-Hematological Patients
Background: Chemotherapy-Induced Peripheral Neuropathy (CIPN) is a side effect common to many drugs in cancer treatment. CIPN symptoms are mainly sensory, as paresthesia and pain, especially in body extremities. It can affect the patient’s life, requiring a dose reduction or interruption of therapy, which can impact patien.. Read More
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Background: To evaluate the association between mobile/cellular phone use and risk of three intracranial tumors (glioma, meningioma and acoustic neuroma) based on case-control studies through pooling the published data. Methods: We conducted a systematic literature search in databases including PubMed, EMBASE, and the Cochrane .. Read More
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Purpose: Typically, before the Y90 Radioembolization procedure undergoes, a CT is completed and the Barbeau test followed by radial artery ultrasound is used to determine if the artery is sufficiently large for vascular access. 2.5 mm is the average radial artery diameter, and a vessel measurement of 2.0 mm is the recommended mi.. Read More
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A Checkpoint Inhibitor-Based Immunotherapy (ICIs) has demonstrated outstanding efficacy in many solid tumors. However, some treated patients with positive expression of PD-L1 do not respond, and even develop hyper progression, and some patients with negative expression of PD-L1 can also benefit from immunotherapy combined with c.. Read More
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Comprehensive Pan-cancer Analysis of 33 Human Cancers Reveals the Immunotherapy Value of FOXP3
Background: Previous studies reported that FOXP3 is involved in the regulation of tumor microenvironment and the regulation of tumor local immunity. However, its mechanism has not been fully studied. This study aims to explore the potential relationship between FOXP3 and cancer immunotherapy in 33 human cancers. Methods: The ge.. Read More
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