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As the use of immune checkpoint inhibitors (ICIs) expands in clinical practice, our understanding of their potential adverse effects continues to grow. Arising substantiation indicates a connection between ICI remedy and an increased threat of accelerated atherosclerosis and atherosclerotic cardiovascular (CV) events. In this di.. Read More
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Chronic low-grade inflammation has a role in coronary atherosclerosis, resulting in a variety of clinical symptoms such as asymptomatic to stable angina, acute coronary syndrome, heart failure, and sudden cardiac death. Coronary microvasculature is made up of vessels with a diameter of less than 500 m, and structural and functio.. Read More
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Heat shock proteins (HSPs) were discovered in the early 1960s as important intracellular proteinaceous components that aid in stress physiology and reprogram cellular responses to allow the organism to survive. HSPs were discovered in extracellular spaces in the early 1990s and were shown to activate gamma-delta T-lymphocytes. S.. Read More
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This study focuses on atherosclerosis, a prominent cause of cardiovascular disease (CVD). Atherosclerosis is a chronic inflammatory disorder characterised by immunological competent cells in lesions that primarily generate proinflammatory cytokines. The presence of dead cells and oxidised versions of low density lipoproteins (ox.. Read More
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Atherosclerosis, a chronic inflammatory disease of the arterial walls, is characterized by intricate cellular heterogeneity within the plaques. The identification of highly plastic and heterogeneous cell populations has added a layer of complexity to atherosclerosis research, challenging traditional cell markers used for plaque .. Read More
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The utilization of single cell technologies, lineage tracing mouse models, and advanced imaging techniques has significantly enhanced our understanding of the cellular landscape of atherosclerosis. These advancements have provided a clearer resolution of the diverse cellular states involved in the progression of atherosclerosis... Read More
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Atherosclerosis is a condition characterized by the hardening and narrowing of the highways, which can lead to health complications such as heart attacks, strokes, and peripheral artery disease. The accumulation of shrine within blood vessels can make them fragile and prone to rupture, leading to the formation of blood clots tha.. Read More
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Knowledge of Ischemic Heart Disease: Causes, Signs, Evaluation, and Management
Ischemic Heart Disease (IHD), characterized by reduced blood supply to the heart muscle, poses a significant global health challenge. This article comprehensively explores the causes, signs, evaluation, and management of IHD. The primary cause, atherosclerosis, is examined in conjunction with modifiable risk factors such as smok.. Read More
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Endothelial Dysfunction: Understanding the Underlying Causes and Implications
Endothelial dysfunction is a critical factor in the development and progression of various cardiovascular and metabolic diseases. This article explores the intricacies of endothelial dysfunction, its underlying causes, and implications. The endothelium, a single layer of cells lining blood vessels, plays a pivotal role in mainta.. Read More
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Understanding Lipoproteins: Key Players in Cardiovascular Health
Lipoproteins, complex molecular assemblies of lipids and proteins, are essential components of the circulatory system, serving as vehicles for the transport of lipids, including cholesterol and triglycerides, throughout the body. This article provides an overview of lipoproteins, their various types, functions, and their critica.. Read More
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The Role of High-Density Lipoprotein (HDL) in Cardiovascular Health
High-Density Lipoprotein (HDL), often referred to as “good cholesterol,” is a crucial component of the lipid profile with a pivotal role in maintaining cardiovascular health. This article explores the structure, function, and importance of HDL in the context of cardiovascular well-being. HDL’s primary functions.. Read More
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Understanding Peripheral Artery Disease: Causes, Symptoms, and Treatment
Peripheral Artery Disease (PAD), a common vascular condition, arises from atherosclerosis, resulting in narrowed or blocked arteries, predominantly in the legs. The causes and risk factors for PAD encompass smoking, diabetes, high blood pressure, high cholesterol, age, family history, obesity, and inactivity. Symptoms include in.. Read More
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Recognizing the Quiet Danger: Plaque Development and Its Effects on Health
Plaque development, whether in the context of oral health or within the arteries, represents a significant yet often underestimated threat to overall well-being. This article sheds light on the diverse nature of plaque, with a specific focus on arterial plaque, its origins, and the profound health consequences it can yield. From.. Read More
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Exploring the Intricate Network of Blood Vessels: Anatomy, Function, and Health
The circulatory system, with its complex and intricate network of blood vessels, forms the lifeline of the human body, responsible for sustaining every cell, tissue, and organ. This article provides an in-depth exploration of blood vessels, encompassing their diverse types, anatomical structures, and multifaceted functions. From.. Read More
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Myocardial Infarction: Understanding the Heart Attack
Myocardial infarction, commonly known as a heart attack, is a life-threatening medical condition that results from the blockage of blood flow to the heart muscle. This article provides a comprehensive overview of myocardial infarction, encompassing its causes, risk factors, symptoms, diagnosis, treatment, and prevention. The pri.. Read More
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Aortic Plaque: A Comprehensive Exploration of Its Causes, Consequences, and Management
Aortic plaque, also known as aortic atherosclerosis or aortic atheroma, is the accumulation of fatty deposits and cholesterol on the inner lining of the aorta, the body’s largest artery. This article offers a comprehensive exploration of aortic plaque, examining its causes, consequences, and management. The causes of aorti.. Read More
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Sleep Disorders in Patients with Parkinson Disease and Its Correlation to Motor Symptoms Severity
Background: Sleep disturbances are non-motor manifestations, which occurs in up to 96% of patients with Parkinson’s disease (PD). They include insomnia, disorders of daytime somnolence, sleep-related breathing disorders,restless legs syndrome (RLS), and rapid eye movement behavior disturbances. Sleep disorders have signifi.. Read More
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Understanding Atherosclerosis: Unraveling the Intricacies of Arterial Plaque Formation
Atherosclerosis, a complex and insidious cardiovascular condition, represents a paramount challenge to global health. This article delves into the multifaceted landscape of arterial plaque formation, a pivotal process in the genesis of atherosclerosis. From the delicate endothelial lining to the dynamic evolution of plaque, we u.. Read More
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Ischemia, a complex medical condition rooted in inadequate blood supply to vital organs or tissues, stands as a profound challenge in healthcare. This comprehensive exploration delves into the multifaceted landscape of ischemia, elucidating its diverse causes, subtle symptoms, and the latest breakthroughs in treatment strategies.. Read More
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Understanding Hyperlipidemia: Causes, Effects, and Management
Hyperlipidemia, characterized by elevated levels of lipids in the blood, poses a significant risk to cardiovascular health. This article delves into the causes, effects, and management strategies associated with hyperlipidemia. Genetic factors, diet, sedentary lifestyle, obesity, and certain medical conditions contribute to its .. Read More
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