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It is established that p-cresol, a compound produced by bacterial colonies within the gastrointestinal tract of mammals, plays a contributory role in the manifestation of various mental disorders. Recently, our research demonstrated that diminishing p-cresol levels in the brain adversely impact the behavioral manifestation of co.. Read More
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Introduction: Language and behavioral disorders result from abnormal brain development interfere with the child's language development. When language development impair than behavioral disorders arises. In this perspective, Magnetic Resonance Imaging (MRI) analysis can help to identify the causes of these disorders, allowing the.. Read More
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A Review on Late-Stage Dementia Residents
We delved into the efficacy of the Reading Buddies Program (RBP), wherein graduate students in occupational therapy engage in book reading sessions with institutionalized persons grappling with dementia. Our focus was on assessing the extent to which residents were engaged during these sessions. Additionally, we scrutinized the .. Read More
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Background: Neurological emergencies are frequent presentations and often end with devastating short and long term consequences. Neurological disorders are increasingly prevalent in Sub-Saharan Africa with paucity of data on adult neurological emergencies in our context. Methods: A prospective cross-sectional study enrolled 103.. Read More
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Severe Cerebellar Atrophy Following Acetylsalicylate Poisoning: A Case Report
Introduction: Acetylsalicylate is a common Over-The-Counter (OTC) drug that is used for suicide attempts. Acetylsalicylate toxicity ranges from mild to death, according to the amount that is taken and the response of the patient. In particular, toxicity may occur in a delayed manner, causing serious damage to the brain as a sequ.. Read More
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Nilotinib Single-Dose Pharmacokinetics and Pharmacodynamics in Parkinson's Disease Patients
With the strongest affinity for inhibiting Abelson (c-Abl) and Discoidal Domain Receptors (DDR1/2), nilotinib is a broad-based tyrosine kinase inhibitor. According to preclinical data, nilotinib lowers brain alpha-synuclein levels and lessens inflammation in Parkinson's Disease (PD) animals. As we previously demonstrated, niloti.. Read More
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Objective: To evaluate the therapeutic effects of surface Neuromuscular Electrostimulation (sNMESS) and Masticatory Device with Hyperboloid (MDHB) on Masticatory Biomechanical Function (MBF) in Down Syndrome (DS). Their influences on salivary parameters, sleep disorders and body adiposity and their risks were analyzed. Methods:.. Read More
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After early skepticism, the association between Gaucher Disease (GD), a rare genetic disease and Parkinson's Disease (PD), the second most common neurodegenerative disorders, is well established, but its underlying mechanisms is controversial: loss of function (haploinsufficiency) or gain of function. Both approaches are support.. Read More
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A Blood Screening Test for Dementia with Lewy Bodies for Primary Care
Introduction: We sought to cross-validate our previously published blood test for detecting Dementia with Lewy Bodies (DLB). Method: Plasma samples were analyzed on 428 individuals (DLB n=89, Parkinson’s Disease (PD) without dementia n=126, Alzheimer’s Disease (AD) n=108, Normal Controls (NC) n=105). Results: The p.. Read More
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Sleep Disorders in Patients with Parkinson Disease and its Correlation to Motor Symptoms Severity
Background: Sleep disturbances are non-motor manifestations, which occurs in up to 96% of patients with Parkinson's Disease (PD). They include insomnia, disorders of daytime somnolence, sleep-related breathing disorders, Restless Legs Syndrome (RLS) and rapid eye movement behavior disturbances. Sleep disorders have significant i.. Read More
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Impact of Acupuncture on Fatigue Management in Individuals with Parkinson's Disease
Parkinson’s Disease (PD) is the second most common neurodegenerative disease in the United States, effecting approximately a million Americans every year. Though the disease is not fatal, it puts patients at risk for other causes of morbidity and mortality (example: falls, aspiration, serious infections). Along with classi.. Read More
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Diagnosis and Multidisciplinary Care for a 72-Year-Old Alzheimerâs Patient: A Case Report
Alzheimer's Disease (AD) is a relentless and progressive neurodegenerative disorder that inflicts profound cognitive decline, memory impairment, and functional limitations upon those it affects. This case report serves as a comprehensive exploration of the clinical journey of a 72-year-old female patient, vividly illustrating th.. Read More
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Amytrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder defined by its effects on both Upper Motor Neurons (UMN) and Lower Motor Neurons (LMN). ALS typically spares other neurologic functions (sensory, autonomic, etc), however case reports show rare instances of extrapyramidal, cerebellar, sensory and autonomic degene.. Read More
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Background: The most prevalent cause of dementia, which is a significant cause of disability in the elderly, is Alzheimer's disease (AD). A large number of novel treatments have been approved to treat AD, but to date none have been able to stop the progression of the disease, and sadly they are all linked to side effects, necess.. Read More
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A Case Report on Challenges Faced in Early-Onset Dementia in Middle-Aged
This case report presents the clinical profile, diagnostic evaluation, and management of early-onset dementia in a 55-year-old male patient. The aim is to shed light on the challenges faced by individuals with early-onset dementia and the importance of timely diagnosis and appropriate interventions. The case highlights the impac.. Read More
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The Impact of Air Pollution on Dementia and Preventive Measures: Two Focus Groups Study in China
Background: Despite research identifying a possible association between air pollution exposure and dementia risk, no study has investigated the perceptions, knowledge, attitude, and experiences of the caregivers of people with dementia on this topic. This article presents a qualitative study to identify these from the dementia c.. Read More
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Bismuth Toxicity as a Cause of Parkinsonism
Parkinsonism” or a “Parkinsonian appearance” describes a cluster of neurologic signs and symptoms related to movement, such as rigidity, tremor, and abnormal gait. The list of causes is wide, the most common and memorable of which are neurodegenerative disorders (such as parkinson’s disease, corticobasal .. Read More
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Introduction: This study examined how well group cognitive behavioral therapy treated anxiety and depressive symptoms in Parkinson's disease patients. Methods: The experimental and control groups participated in this quasi-experimental study's pretest, posttest, and follow-up phases. Patients aged 60 to 75 from psychiatric and .. Read More
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Background: Despite the negative effects of depression in Parkinson's disease, there is currently no evidence-based standard of care. Objective: The purpose of this study was to investigate the effectiveness of group cognitive behavioral therapy in depression and anxiety symptoms in patients with Parkinson's Tehran city. Metho.. Read More
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Background: There has been increased research investigating the utility of plasma biomarkers of Alzheimer’s disease as diagnostic markers, predictors of risk and progression. Although there is extensive evidence pointing to sex differences in epidemiology, vulnerability, pathology and progression of AD there is a dearth of.. Read More
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