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Since long, in fact from the beginning of life organisms have confronted various environmental toxicants. The growing literature has provided enormous epidemiological studies regarding metalinduced carcinogenicity. Among these principally considered cancerinducing metals are arsenic, chromium, cadmium and nickel. Our intension over here is to focus on contemporary and novel targets for metal causing cancer, since a comprehensive and broad understanding of these targets may help researches develop combinatorial modalities against metal-induced carcinogenesis.