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During early stages of eosinophil development, intense bursts of protein production during normal biological processes put strain on the endoplasmic reticulum (ER), which plays a crucial role in protein synthesis and transport. If the ER is overwhelmed by such strain, the cell enters ER stress. In response to ER stress, a protein called IRE1α helps to generate a highly active form of a second protein called XBP1, which in turn regulates the activity of various genes involved in the cell stress response. This signaling pathway reduces ER stress and prevents cell death by enhancing the ER's protein synthesis capacity while reducing overall protein production. Taken together, the findings suggest that ER health is crucial for eosinophil development and survival, highlighting the IRE1α/XBP1 pathway as a potential therapeutic target in a wide variety of eosinophil-mediated diseases.
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