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From his Ph.D. to today, he has aimed to understand the fundamental mechanisms of gene regulation in human inflammatory or tumoral pathologies (>40 articles). Since my recruitment as Senior Researcher in 2010 at INSERM, He has studied mechanisms of original regulations of the miRNAs in human pathologies (>30 articles). His main results are: 1 / Demonstration that a synonymous polymorphismon the GWAS-associated IRGM gene with Crohn's disease can disrupt the regulation of RNA by loss of miRNA binding, resulting in aberrant IRGM expression. These results lead him to revisit in a very significant way our vision of the consequences of mutations synonymous in pathophysiological mechanisms. (Nature Genetics, 2011; Autophagy, 2011, 4 reviews) 2 / Determination of miRNA signatures to classify patients in pulmonary pathologies (PlosOne, 2013), and miRNA predisposing to an effective therapeutic response (Oncotarget, 2016). These results suggest the use of miRNAs as a complementary tool for clinical diagnosis, prognosis or therapy. 3 / Demonstration of transient reprogramming (ie EMT) of tumor cells through a novel mechanism combining the phagocytosis of extracellular miRNAs when contacting inflammatory cells / tumor cells and its degradation by an XRN1 exonuclease. These results demonstrate that the plasticity of tumor cells is due to the instability of extracellular microRNAs once phagocytosed, a new notion explaining the transient and transient mesenchymal and then epithelial transitions of tumor cells (Nucleic Acids Research, 2017). His future research project aims to work on functional genomics and on the regulation of non-coding RNA.
Single nucleotide polymorphisms
Non coding genome
Non coding RNA
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