Neuropathology of AD in the very old demented subjects differs considerably in both intensity and distribution from that in younger age groups. Increased densities of neuritic plaques and NFTs are absent in non-demented patients over age 85-90, and there is considerable overlap in the pathologies found in demented and non-demented patients. The synergistic interaction between Aβ, tau, and αSyn, accelerating neuropathology and cognitive decline, has been summarized recently.
Open access Neuropathology Journal is an International peer-reviewed journal which publishes research in all the fields of Neuropathology. Once published open access, author work will be made available online, ensuring the widest possible exposure of the author research.
Last date updated on April, 2024
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