Mammalian Heart

"Mammalian heart has been considered as a post-mitotic organ composed of highly specialized and terminally differentiated cardiac myocytes. Mammalian cardiac myocytes have traditionally been considered as post-mitotic cells with an extremely low or practically no capacity to divide and regenerate. However, lower vertebrates such as fish and amphibians retain a substantial capacity for myocardial regeneration. In adult frogs and newts, differentiated cardiac myocytes have the ability to undergo mitotic division after damage to the heart. This regenerative process involves a partial cellular dedifferentiation characterized by the disassembly of the sarcomeres and supporting cytoskeleton in the myocytes before the initiation of mitotic cycle. Recently, it has been shown that mammalian cardiac muscle has limited proliferative potential and restricted regeneration within the damaged myocardium. Hence, it may be beneficial to explore the limited natural capacity of mammalian cardiac muscle regeneration in light of the spontaneous cardiac muscle regeneration observed in these lower vertebrate animals. (Mani T. Valarmathi and John W. Fuseler- Mammalian Cardiac Muscle Regeneration: Structural and Functional Modulation of Adult Marrow Stromal Stem Cells)"

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Last date updated on September, 2024