Carcinoid Research

In this brief article, three topics, unrelated to each other, are emphasized;a mysterious mechanism of the earliest carcinoid formation, reevaluation of original drawing of the submucosal nodule, and a consideration of terminology for this tumor. Grimelius- positive cells (G-cells) in a gastric gland derived from an African rodent.On the left: the upper portion of the gland is entirely replaced by G-cells but the configuration of the gland is well preserved. The lower portion is distorted with irregularly arranged G-cells apparently invading into the surroundings. Thus, one gland displays different stages of G-cell proliferation; intraglandular preneoplastic - or frankly neoplastic-cell proliferation, and extraglandular (intramucosal) neoplastic-cell proliferation with “budding phenomenon”. As a whole this gland discloses earliest carcinoid formation and its malignancy at its origin. On the right: one of multiple consecutive serial sections of the same gland apart from the center exhibits somewhat blurred and distorted configuration of the gland in the upper portion but without definite invasion, while obvious invasion to the surroundings is evident in the lower portion.

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Last date updated on April, 2024