Rheumatoid Arthritis

Rheumatoid arthritis (RA) is an autoimmune disease, associated with a chronic inflammatory status, and increased levels of cytokines which are implicated in the destruction of joints. The disease can develop at any age but most often occurs in people between age 25 and 50, and is more common among women, with a worldwide prevalence rate of approximately 1%. Periodontal disease (PD) is an infection of the tissue that surrounds and supports the tooth structure, resulting also in a chronic inflammatory status. The severe generalized form of periodontal disease has a global prevalence rate of 5%-15%. Several associations have been reported between PD and other diseases such as RA, hypertension, and diabetes Mohammed Hammoudeh: Ahmed Al-Momani: Magdi Hassan Abdelrahman: Prem Chandra and SamerHammoudeh, Prevalence and Association of Periodontal Disease among Rheumatoid Arthritis Patients in Qatar: A Cross Sectional Study “Rheumatoid Arthritis (RA) is a chronic systemic auto immuneinflammatory disease affecting mostly the joints as well as otherorgans. Genetic factors may play a big role in the pathogenesis of RA.Genes encoded within HLA DRB1 provide the most consistent geneticevidence. It is well recognised that HLA DRB1 shared epitope alleleslargely influence development of seropositive RA and specifically AntiCCP positive disease. Smoking is a very important environmentalfactor. Other suggested environmental factors include obesity, silicadust, exposure to mineral oils and socio-economic class. Viruses andmycoplasma organisms may also be implicated.

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Last date updated on September, 2024