Drug Target Journals

Notch signaling pathway is a conserved developmental pathway which is involved in cell fate determination at the stage of embryonic development and also plays important roles in tissue and organ development, hematopoiesis, vascular growth. Most of the cancer cell lines have shown significant level of up regulation of its activator proteins and down regulations of its suppressor proteins. The “gain or loss” of functions of these Notch pathway associated proteins have clearly proved its correlation with cancer development, and hence can be used as a biomarker for cancer diagnosis. Various molecular biology experiments have also shown that inhibition of the activators of this pathway can drastically reduce the cancer progression in different stages , hence identification of drug targetable proteins and their small molecule inhibitors in the pathway to reduce various types of cancer development is always been an important field of research to the pharmacists and clinical biologists. Recent identification of GAMMA SECRETASE as a probable drug target in the pathway is found to reduce the Notch pathway activity by not allowing it to cleave the Notch receptor in the membrane. Identification of suitable and alternative drug targets for inhibition of this pathway in various cancers including Glioblasotma are undoubtedly useful and effective for cancer therapy , but requires the understanding of the exact mechanisms that are governing the normal functions of Notch signaling pathway in functional cells.(Chowdhury S, Sarkar RR, Drug Targets and Biomarker Identification from Computational Study of Human Notch Signaling Pathway)

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Last date updated on September, 2024