Gene Regulatory Network

Genes act as blue print of every living object‘s activity. Genes produces proteins, this protein or a set of proteins produced by other genes switches on or off or regulates the protein formation activity of other genes. Thus genes form a gene regulatory network, study of which appears to be very important to find the cause of a disease and the solution thereof i.e., ‘Drug design’. This is a sort of reverse engineering activity where end result is given i.e. dataset of a diseased person is given. From there we need to go back to normal person‘s gene network configuration by rectifying the erring network pathway. In computational point of view, a gene regulatory network is represented by a model or graph which represents regulations or interactions amongst genes using a directed graph. Sudip Mandal, Reconstruction of Dominant Gene Regulatory Network from Microarray Data Using Rough Set and Bayesian Approach

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Last date updated on September, 2024