The effects of placental ischemia on blood pressure and many facets seen in preeclampsia can be attenuated with inhibition of T cells either by blockade of antigen presenting cells interacting with T cells or by overall T cell deficiency. Importantly, these data suggests the potential use of anti- inflammatories targeting T cell suppression as a therapeutic for preeclampsia. These studies highlight the importance of targeting CD4+ T cell suppression as an avenue to decrease blood pressure, cytokine production, anti-angiogenic factors, autoantibodies and uterine artery v resistive index to improve preeclampsia symptoms late in pregnancy in PE women.
Last date updated on September, 2024