Influenza-related pneumonia is an important complication of influenza, and it has been suggested that excessive inflammatory reactions, including ââ¬Åcytokine stormââ¬Â, may contribute to the mechanisms underlying severe pneumonia. Human data and mice co-infected with influenza virus and Streptococcus pneumoniae show increased severity of illness according to the elevation of cytokines/chemokines, and mice with genetic knock-out of immune molecules such as Toll-like receptor 3 and IRAK-M also show hyper-immune responses and reduced survival following influenza virus infection. Such findings suggest that innate immune responses and excessive neutrophil activation might be related to severe inflammatory changes in the lungs, and immunomudulatory therapy may thus be effective against severe influenza-related pneumonia.
Mechanisms of Increased Severity of Influenza-Related Pneumonia-Masafumi Seki
OMICS Group International is one of the leading Open Access Publishers which is publishing 700+ peer-reviewed journals. Journal of Tropical Diseases & Public Heath is one of the top Peer-reviewed open access journals that emphasises Malaria, dengue, HIV/AIDS, treatment of infections with their Therapeutic & diagnostics aspects. It publishes original research articles, novel, and scientifically sound findings dealing with tropical diseases related to human health.
Last date updated on September, 2024
Spanish 
Chinese 
Russian 
German 
French 
Japanese 
Portuguese 
Hindi