Iron Chelation Therapy

Iron is absolutely essential to living cells and plays many important roles in energy production, oxygen transport and DNA synthesis. Although iron is crucial for cells, an excess of iron is toxic. In thalassemia patients, multiple blood transfusions and abnormal iron absorption cause iron overload and accumulation in tissues and organs. Consequently, reactive oxygen species (ROS) are produced from the iron-catalyzed Fenton reaction, causing oxidative tissue damage and organ dysfunctions. Iron chelation therapy is required, not just to restore iron balance, but also to reduce toxic iron species. Iron chelators, such as desferrioxamine (DFO), deferiprone (DFP) and deferasirox (DFX), are available for clinical use. Due to many side effects and drawbacks of available chelators, novel oral bidentate iron chelator CM1 is synthesized, it is an analogue and is more lipophilic than DFP. CM1 was able to bind both ferric and ferrous ions, and was also able to chelate plasma non-transferrin bound iron (NTBI), efficiently. CM1 was not toxic to peripheral blood mononuclear cells and liver cells in an in vitro study. Somdet Srichairatanakool https://www.omicsonline.org/open-access/toxicity-study-of-a-novel-oral-iron-chelator-nacetylaminohexyl-hydroxymethylpyridinone-cm-in-transgenic-bthalassemia-mice-vms.1000116.php?aid=16304 Vitamins & minerals is one of the best indexed journals in the field of nutrition and essential micro nutrients field of science, publishes the ongoing scientific research in the form of original research, review, case reports, editorials with the main focus on the quality of publishing. By the eminent personalities from the editorial and reviewer board, ensuring of the high quality and originality of the published content is achieved. OMICS Group International has been indexing all articles of Vitamins & minerals to enhance visibility and credibility. It has a repertoire of over 700+ peer-reviewed journals of which, quality and originality are insured by 50,000+ editorial board members.

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Last date updated on September, 2024