The role of genetics/ heredity in multiple sclerosis is not yet known. But there are cases where multiple sclerosis gets passed through generations as well as there are cases where the risk of multiple sclerosis seems to be high in siblings. Since this being a controversial topic in the field of MS research, our journal considers this a hot topic to be investigated further.
ââ¬ÅGenetic research aimed at the identification of specific genes associated with pathways involved in the pathogenesis of MS continues growing, providing an overwhelming amount of new data. Multiple genome-wide association screens in MS have been completed in the past five years, expanding the list of risk loci and supporting the view that MS susceptibility results from multiple common allelic variants. In 2013, the International Multiple Sclerosis Genetic Consortium (IMSGC) revealed another 48 genetic polymorphisms contributing to risk of disease. Although more than 100 genes have been described as involved with an increased risk of MS, many genetic polymorphisms could not be clearly associated with specific changes in protein expression. How these genes increase susceptibility to develop MS is a question which remains openââ¬Â Silvia Tenembaum et al., Review on Recent Advances in Multiple Sclerosis and Related Disorders.
Last date updated on September, 2024
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